Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Indianapolis (W Vermont St) | Cheapest | ||||
 | Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | Fastest |
Last refresh of the prices: Yesterday at 10:25 PM CDT.
Get from Tupelo to Indianapolis
The journey takes about 21 hours 30 minutes, and with fares starting at just R$393, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 88123 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at R$398
Frequently asked questions about travelling from Tupelo to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Indianapolis?
The cheapest bus tickets from Tupelo to Indianapolis start from R$393. The average price for this route is around R$521. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Indianapolis?
The average bus travel time from Tupelo to Indianapolis is 21h 30m, covering a distance of 655 km. The quickest bus can get you there in 13h 25m and is operated by Greyhound.
Which bus companies service the Tupelo to Indianapolis route?
Several major bus companies operate on this route with 4 buses available per day.
What are the earliest and latest departure times for the bus from Tupelo to Indianapolis?
The earliest bus departs from Tupelo to Indianapolis at 5:35am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to Indianapolis?
A bus trip from Tupelo to Indianapolis generates an estimated 16.363125 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Indianapolis was searched and found on Sep 8, 2026 with a price of R$413To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Indianapolis, as early as possible.
You can expect to pay from R$413 to R$760 for a bus ticket from Tupelo to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at R$413 which is on 2026-09-08.
