Next bus departures

Next departures for Prague to Brussels on August 28
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	3:25am	Prague (Main Station - parking)	14h 30m	5:55pm	Brussels North Train Station	Cheapest
Bus	11:05am	Prague (Central Bus Station Florenc)	13h 20m	12:25am	Brussels North Train Station	Fastest
Bus	7:20am	Prague (Central Bus Station Florenc)	22h 5m	5:25am	Brussels Airport BRU (Parking P14)	No tags
Bus	4:00pm	Prague (Central Bus Station Florenc)	17h 25m	9:25am	Brussels Airport BRU (Parking P14)	No tags
Bus	6:00pm	Prague (Central Bus Station Florenc)	18h 30m	12:30pm	Brussels Airport BRU (Parking P14)	No tags
Bus	8:00pm	Prague (Central Bus Station Florenc)	16h 40m	12:40pm	Brussels Airport BRU (Parking P14)	No tags
Bus	11:40pm	Prague (Central Bus Station Florenc)	17h 10m	4:50pm	Brussels Airport BRU (Parking P14)	No tags
Bus	1:00am	Prague (Main Railway Station)	15h 50m	4:50pm	Brussels Airport BRU (Parking P14)	No tags

Last refresh of the prices: Yesterday at 6:06 PM CEST.

Compare 2 ways to go from Prague to Brussels

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 17 hours 45 minutes and with fares starting at just MX$729, it presents an excellent value for a comfortable ride.

39bus per day

17h 45mAverage Duration

442 milesDistance

18kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PriceMX$729 - MX$3,281	Average Duration17h 45m	CO₂ emissions 18kg CO₂e
Train	Average PriceMX$2,048 - MX$4,769	Average Duration16h 27m	CO₂ emissions 17kg CO₂e

Bus stations and stops in Prague and Brussels

Stops in Prague

A
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic
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B
PRG Airport
Aviatická, 161 08, Praha 6, Czechia
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C
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic
D
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
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E
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
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F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
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Stops in Brussels

A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium
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B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
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C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
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Compare companies

FlixBus

3.5/515,376 reviews

Staff4.1

Timeliness4.0

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

RegioJet

4.1/51,103 reviews

Staff4.5

Timeliness4.1

Cleanliness4.4

Wifi3.8

BlaBlaCar Bus

3.7/512,706 reviews

Staff4.3

Timeliness3.7

Cleanliness4.3

Wifi2.6

BE bus companies:FlixBus, BlaBlaCar Bus, Deutsche Bahn, Sindbad, Ecolines, KLR Bus, RegioJet

Frequently asked questions about traveling from Prague to Brussels by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Prague to Brussels?
The cheapest bus tickets from Prague to Brussels start from MX$729. The average price for this route is around MX$1,716. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Brussels?
The average bus trip duration from Prague to Brussels is 17h 45m, covering a distance of 442 miles (713 km). The quickest bus can get you there in 12h and is operated by RegioJet.
Which bus companies service the Prague to Brussels route?
Several major bus companies operate on this route with 39 buses available per day, including services from FlixBus, RegioJet, BlaBlaCar Bus.
What is the earliest and latest departure time for the bus from Prague to Brussels?
The earliest bus departs from Prague to Brussels at 12:10am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Prague to Brussels?
A bus trip from Prague to Brussels generates an estimated 17.816775 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Prague to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1103 reviews.
Which bus company has the best Wi-Fi from Prague to Brussels?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Prague to Brussels?
According to Busbud traveler reviews, the most timely bus company on this route is RegioJet, with a punctuality rating of 4.1 out of 5 stars.
Which bus company has the cleanest buses from Prague to Brussels?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08/25

MX$1,225

08/26

MX$1,184

Today

MX$1,911

08/28

MX$1,349

08/29

MX$1,299

08/30

MX$1,287

08/31

No data

09/01

MX$769

The cheapest trip from Prague to Brussels was searched and found on Sep 1, 2026 with a price of MX$769

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.

You can expect to pay from MX$769 to MX$3,124 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at MX$769 which is on 2026-09-01.